Eco-Friendly Synthesis of 2-Styryl-benzo[d][1,3]oxazin-4-ones
from N-Cinnamoyl-Anthranilic Acids
Molecules 2026, 31, 709
https://doi.org/10.3390/molecules31040709
Abstract:
N-cinnamoyl anthranilic acids are synthesized in a single, eco-friendly step by condensing
various cinnamic acids with free 2-aminobenzoic acid derivatives using the mixed carbonic
anhydride method. Subsequently, converting the resulting N-cinnamoyl anthranilic acids
into their corresponding mixed carbonic anhydrides rapidly and efficiently affords 2-styryl-
benzo[d][1,3]oxazin-4-ones. The method employs green solvents, such as acetone and
2-methyltetrahydrofuran; does not require metal catalysts or reflux conditions; and yields
the desired final products without chromatographic purification.
Keywords: benzo[d][1,3] oxazin-4-ones; anthranilic acids; hydroxycinnamic acids
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